The Biostatistics of Aging
From Gompertzian Mortality to an Index of Aging-Relatedness
Nonfiction, Health & Well Being, Medical, Reference, Biostatistics, Ailments & Diseases, Infectious Diseases, Epidemiology, Science & Nature, Mathematics, Statistics
| Author: | Gilberto Levy, Bruce Levin | ISBN: | 9781118645826 |
| Publisher: | Wiley | Publication: | February 11, 2014 |
| Imprint: | Wiley | Language: | English |
| Author: | Gilberto Levy, Bruce Levin |
| ISBN: | 9781118645826 |
| Publisher: | Wiley |
| Publication: | February 11, 2014 |
| Imprint: | Wiley |
| Language: | English |
A practical and clarifying approach to aging and aging-related diseases
Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population.
With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features:
- Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values
- A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations
- The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology
- An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles
- The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software
- Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases
The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.
A practical and clarifying approach to aging and aging-related diseases
Providing a thorough and extensive theoretical framework, The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness addresses the surprisingly subtlenotion—with consequential biomedical and public health relevance—of what it means for acondition to be related to aging. In this pursuit, the book presents a new quantitative methodto examine the relative contributions of genetic and environmental factors to mortality anddisease incidence in a population.
With input from evolutionary biology, population genetics, demography, and epidemiology, this medically motivated book describes an index of aging-relatedness and also features:
- Original results on the asymptotic behavior of the minimum of time-to-event random variables, which extends those of the classical statistical theory of extreme values
- A comprehensive and satisfactory explanation based on biological principles of the Gompertz pattern of mortality in human populations
- The development of an evolution-based model of causation relevant to mortality and aging-related diseases of complex etiology
- An explanation of how and why the description of human mortality by the Gompertz distribution can be improved upon from first principles
- The amply illustrated analysis of real-world data, including a program for conducting the analysis written in the freely available R statistical software
- Technical appendices including mathematical material as well as an extensive and multidisciplinary bibliography on aging and aging-related diseases
The Biostatistics of Aging: From Gompertzian Mortality to an Index of Aging-Relatedness is an excellent resource for practitioners and researchers with an interest in aging and aging-related diseases from the fields of medicine, biology, gerontology, biostatistics, epidemiology, demography, and public health.
