Comparative Pathophysiology and Toxicology of Cyclooxygenases

Nonfiction, Science & Nature, Science, Chemistry, Organic
Cover of the book Comparative Pathophysiology and Toxicology of Cyclooxygenases by Zaher A. Radi, Wiley
View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart
Author: Zaher A. Radi ISBN: 9781118351901
Publisher: Wiley Publication: August 15, 2012
Imprint: Wiley Language: English
Author: Zaher A. Radi
ISBN: 9781118351901
Publisher: Wiley
Publication: August 15, 2012
Imprint: Wiley
Language: English

The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks

Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks.

Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover:

  • The pathophysiology of COX inhibition on bone, tendon, and ligament healing
  • COX inhibitors and renal system pathophysiology and mechanisms of toxicity
  • The pathophysiologic role of COX inhibition in the ocular system
  • COX inhibition and the respiratory and cardiovascular systems

The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.

View on Amazon View on AbeBooks View on Kobo View on B.Depository View on eBay View on Walmart

The first thorough review of cyclooxygenase inhibitors, including their toxicity mechanisms and toxicopathological risks

Cyclooxygenases (COXs) are enzymes responsible for the formation of an important class of biological mediators called prostanoids. Prostanoids such as prostaglandins mediate inflammatory and anaphylactic reactions. For those suffering from inflammation and pain, the pharmacological inhibition of COXs, with non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, can provide relief. Yet the use of NSAIDs can trigger toxicological effects as well, leading to potential health risks.

Comparative Pathophysiology and Toxicology of Cyclooxygenases provides a comprehensive overview of how COX inhibitors affect various bodily systems, specifically the toxicity mechanisms triggered when the COX enzyme is inhibited. The book provides an introduction to the discovery of cyclooxygenases, their use as therapeutic agents, as well as an historical perspective. Shedding light on the differences in expression, pathophysiology, and toxicology of COX inhibitors across species, the book offers a systematic examination of the effects and pathophysiology of COX inhibitors and their mechanisms of toxicity, beginning with the GI tract. Subsequent chapters cover:

The book also sheds light on the latest research devoted to developing COX inhibitors with no adverse side-effects. The first book to offer a thorough comparative look at the toxicological effects of COX inhibitors throughout the body, this invaluable resource will help advance the research and development of safer and more effective COX drugs.

More books from Wiley

Cover of the book Handbook of Psychotherapy in Cancer Care by Zaher A. Radi
Cover of the book Pesticide Risk Assessment for Pollinators by Zaher A. Radi
Cover of the book Flow Cytometry in Drug Discovery and Development by Zaher A. Radi
Cover of the book Work is Love Made Visible by Zaher A. Radi
Cover of the book E-mail and Behavioral Changes by Zaher A. Radi
Cover of the book Metals in Cells by Zaher A. Radi
Cover of the book The City As A Tangled Bank by Zaher A. Radi
Cover of the book Commodity Option Pricing by Zaher A. Radi
Cover of the book Audit and Accounting Guide: Investment Companies by Zaher A. Radi
Cover of the book The Wiley Handbook of Disruptive and Impulse-Control Disorders by Zaher A. Radi
Cover of the book Nuclear Magnetic Resonance Spectroscopy by Zaher A. Radi
Cover of the book Heating Services in Buildings by Zaher A. Radi
Cover of the book Bauphysik Kalender 2012 by Zaher A. Radi
Cover of the book Blues Harmonica For Dummies by Zaher A. Radi
Cover of the book Statistical Arbitrage by Zaher A. Radi
We use our own "cookies" and third party cookies to improve services and to see statistical information. By using this website, you agree to our Privacy Policy